DMSO Technical Articles
Practical guidance on DMSO specifications, grade selection and industrial purchasing.
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DMSO in Clarithromycin Intermediate Synthesis
How DMSO hosts the selective 6-O-methylation of a protected erythromycin intermediate, and why the methyl group comes from methyl tosylate rather than DMSO.
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Why the Same Nucleophile Can Behave Differently in DMSO
Why DMSO’s polar aprotic environment can change nucleophile reactivity, and which factors beyond solvent choice still control rate, selectivity and workup.
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DMSO Is Sometimes a Reagent, Not Just a Solvent
How DMSO acts as a reagent in oxidation sequences such as the Swern oxidation, and which process conditions and specifications matter when scaling them.
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DMSO’s High Boiling Point: Process Window and Downstream Challenge
How DMSO’s high boiling point widens the reactor operating window while creating a downstream engineering challenge, and how to evaluate reaction and workup together.
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DMSO in Peptide Chemistry: Oxidizing Thiols to Disulfide Bonds
How DMSO in aqueous acidic media oxidizes peptide thiols to disulfide bonds, which conditions control the result, and how this differs from thioether cyclization.
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Residual-Solvent Reality: DMSO and DMF Are Not in the Same ICH Class
Why ICH Q3C places DMSO in Class 3 and DMF in Class 2, what the 50 mg per day Option 1 limit means, and why Class 3 is not a free pass.
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Before You Request a DMSO Quote: A Seven-Question Process Screen
A seven-question process screen to complete before requesting a DMSO quotation, covering role, chemistry, moisture, temperature, workup, quality and supply.
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Solvent Selection Guide: 8 Common Solvents Compared
A screening comparison of eight common industrial solvents by physical properties, safety risks and application fit, with DMSO’s position and a practical selection process.
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DMSO Solidification, Thawing and Storage Guide
Why DMSO solidifies in cool storage, how to thaw it safely according to the SDS and container type, and why freezing is not a purity test.
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DMSO in Lithium-Air Batteries: Benefits and Instability Risks
Why DMSO became a leading research solvent for lithium-air batteries through its solution-growth “donut” mechanism, and where its chemical instability still blocks practical use.
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DMSO in PAN-Based Carbon Fiber Production
An end-to-end overview of where DMSO fits in PAN-based carbon-fiber precursor production, and how the spinning, impurity-control and recovery steps connect.
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Regular DMSO vs Deuterated DMSO-d6: Why the Difference Matters
Why regular DMSO and deuterated DMSO-d6 differ so greatly in price, and why only the deuterated form is suitable as an NMR solvent.