DMSO Technical Articles
Practical guidance on DMSO specifications, grade selection and industrial purchasing.
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Carbon Fiber & PAN Precursor, DMSO Fundamentals & Grades, Electronics & Photoresist, Emerging Applications & R&D, Pharmaceutical & Agrochemical Synthesis
Corey–Chaykovsky Epoxidation
Request A Sample The Corey–Chaykovsky reaction transfers a one-carbon methylene unit from a DMSO-derived sulfoxonium salt to aldehydes, ketones, and enones, producing epoxides and cyclopropanes. DMSO is both the reaction medium and the structural parent of the ylide reagent, which makes it the standard solvent for this transformation in pharmaceutical manufacturing. R2C=O + (CH3)2S(O)=CH2NaH, DMSO/THF,…
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Carbon Fiber & PAN Precursor, DMSO Fundamentals & Grades, Electronics & Photoresist, Emerging Applications & R&D, Pharmaceutical & Agrochemical Synthesis
Cyanation Reaction in DMSO
Request A Sample Converting alkyl and aryl halides to nitriles uses cheap inorganic cyanides — NaCN and KCN — that dissolve poorly in most organic solvents. DMSO dissolves these salts and presents the cyanide as a bare, highly nucleophilic anion, which makes it the standard medium for aliphatic and activated aromatic cyanation. R–X + NaCNDMSO,…
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Carbon Fiber & PAN Precursor, DMSO Fundamentals & Grades, Electronics & Photoresist, Emerging Applications & R&D, Pharmaceutical & Agrochemical Synthesis
DMSO in Azole Antifungal Manufacturing
Request A Sample Azole antifungals — imidazoles such as ketoconazole and triazoles such as voriconazole and posaconazole — attach an imidazole or 1,2,4-triazole ring to a hydrophobic side chain through an N–C bond. That coupling is an SN2 alkylation of an azolide salt, a reaction class unusually sensitive to solvent. Dimethyl sulfoxide (DMSO) is the…
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Carbon Fiber & PAN Precursor, DMSO Fundamentals & Grades, Electronics & Photoresist, Emerging Applications & R&D, Pharmaceutical & Agrochemical Synthesis
DMSO in Anti-Tumor Drug Manufacturing
Request A Sample Dimethyl sulfoxide (DMSO) serves three distinct roles in oncology API production: a reaction solvent for reductions and heterocycle assembly, a recrystallization medium for purification, and — in one marketed drug — a structural component of the active substance itself. Where DMSO Is Used in Oncology APIs Capecitabine uses DMSO in a sodium…
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Solvent Selection Guide: 8 Common Solvents Compared
DMSO Key Specs Solvent Boiling Point Dielectric Constant Water Solubility Flash Point DMSO 189 C 47.2 Miscible 95 C NMP 202 C 32.2 Miscible 91 C THF 66 C 7.5 10% -14 C DMF 153 C 36.7 Miscible 58 C Acetonitrile 82 C 37.5 Miscible 6 C Acetone 56 C 20.7 Miscible -17 C DCM…
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How to Thaw and Store DMSO in Winter
DMSO Why DMSO Freezes DMSO melts at 18.4 C. Below that temperature it starts turning solid. A frozen bottle is not a sign of poor quality; it is actually a sign of high purity. Labs without nighttime heating can sit below 15 C, and a 4 C refrigerator will freeze DMSO solid. Correct Thawing Methods…
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DMSO for Lithium-Air Batteries: Benefits and Challenges
DMSO The Electrolyte Problem Conventional electrolytes get oxidized and break down within minutes as a lithium-air battery inhales and exhales oxygen. DMSO, with its high dielectric constant (46 to 48), was tried as a solution and started a years-long debate. How DMSO Helps Donut Growth Mode On discharge, DMSO readily dissolves reaction intermediates, so solid…
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DMSO Core Role in Carbon Fiber Manufacturing
DMSO Why Carbon Fiber Needs DMSO Over 90% of high-performance carbon fiber is made by carbonizing polyacrylonitrile (PAN) precursor fibers. PAN is a stiff polymer that will not dissolve in ordinary solvents. To dissolve it and spin it into uniform, defect-free filaments, a highly polar, powerful solvent is required. DMSO, with its molecular structure, is…
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Regular DMSO vs Deuterated DMSO-d6
DMSO Structural Difference Regular DMSO is (CH3)2SO, with six ordinary hydrogen atoms. DMSO-d6 is (CD3)2SO, with all six hydrogens swapped for deuterium (H-2). Deuterium has an extra neutron, so it weighs twice as much as normal hydrogen. DMSO-d6 is the isotopically labeled version of the molecule. Why It Is Indispensable for NMR Proton NMR picks…
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Decoding DMSO Testing: What Is CPS
DMSO What Is CPS? CPS stands for counts per second. In plain terms, it is how many ions the detector catches every second. The sample is vaporized and ionized in the high-temperature plasma, turning into positive ions. The mass analyzer lets only ions of the target mass through. The ones that reach the detector each…
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Who Is DMSO Best Partner? Comparing Hydrogen Sulfide Sources
DMSO Feedstock Matters In one main production route, hydrogen sulfide (H2S) reacts with methanol to make dimethyl sulfide (DMS), which is then oxidized to DMSO. The source of H2S determines the purity ceiling of the entire downstream chain. Purity and Impurities Refinery or Fertilizer H2S As an environmental byproduct, the stream carries CO2, H2, N2,…
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Don’t Be Fooled by Price: Industrial vs Pharmaceutical vs Electronic Grade DMSO
DMSO Same Purity, Different “Insides” Even when two grades both read 99.9%, the remaining 0.1% is where the grade difference lives. Industrial Grade The priority is dissolving power. Small amounts of heavy metals, some acid-value variation, and trace organic impurities are allowed. Suitable for equipment cleaning, paint stripping, and general synthesis where side reactions are…